FORMULASI SUSPENSION PDF

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FORMULASI SUSPENSION PDF

Keywords: Dry suspension, Taste Masking, Macrolide Antibiotic, Eudragit L . formula F = Vu/Vo, where Vu is the volume of sediment and Vo. Route Dosage Form. Concentration. Sulfamethoxazole-Trimethoprim Oral Suspension 40mg/5mL. Formula Qty: mL. Shelf Life: 20 days. Hospital Of Eastern Ontario. MASTER FORMULA SHEET – NON-STERILE MANUFACTURING. PRODUCT: PROPRANOLOL 5 mg/mL ORAL SUSPENSION .

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Usspension of suspensions One of the methods for making the suspension, is the dispersion of a particle in a vehicle that can be done by mechanical instruments or by the use of surfactants that contains three steps: From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed in the Table 1.

According to the curve each formulation released Author information Article notes Copyright and License information Disclaimer.

Published online Dec Influence of the soluble solids on the zeta potential of suapension cloudy apple juice. Acknowledgement The authors would like to thank Dana Pharmaceutical Co. For 3 of each formulation, dissolution test was performed with USP 2 apparatus Paddle in 50 rpm for 30 minutes. Journal List Adv Pharm Bull v. The sedimentation volume was calculated to be 1 in all the suspensions, therefore there forrmulasi no need to re-dispersion test and the degree of flocculation value was also 1.

Percentage of release for all selected formulations. A sample viscosity curve for formulated suspension.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

Remington the science and practice of Pharmacy. Conflict of interest The authors report no conflicts of interest. J Pharm Biomed Anal. Discussion General criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and homogeneity, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no crystal growth and appropriate pour ability.

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Please review our privacy policy. Assay test Prepared formulations were evaluated by UV system in wavelengths, for the standard solution 20 mg of the drug was dissolved in 50 ml methanol and Tabriz, Iran for the supply of cefuroxime axetil.

Results From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed in the Table 1. Then using equation derived from calibration curve.

The potential of the moving layer around each particle is called zeta potential. Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability. General criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and homogeneity, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no crystal growth and appropriate pour ability.

Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime axetil. Other tests, including measurement of pH, viscosity and zeta potential measurements were performed and finally the best formulations were selected. For suspension formulation equivalent to mg of cefuroxime was suspended in 5 ml supsension, after selecting the type formullasi concentration of wetting agent, other ingredients such as flocculating agents, suspending agents, preservatives and flavors were added.

Quantity of zeta potential can indicate the potential stability of the colloidal system, if the particles have a large positive or negative zeta potential they will have a tendency to repel each other and in too low zeta potentials particles will accumulate and attract each other.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

The viscosity curves showed that the systems were pseudo plastic and thixotrop. There was no sediment in selected formulations and the sediment volume was 1 for all of them so there was no need for re-dispersion test and the degree of the flocculation was also 1 that was probably rormulasi of the high viscosity of the system.

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Eur J Pharm Biopharm. Considering no sedimentation, the sedimentation volume was determined to be 1. Pharmaceutical suspensions from formulation to manufacturing.

After calculating the viscosity, the curves of viscosity against shear rate were plotted. This article is based on a thesis submitted for Pharm Dr degree No. The stability of the amorphous form of cefuroxime axetil in solid state. A new approach to HPLC analysis of medicinal suspensions.

This article has been cited by other articles in PMC. Tabibi S, Rhodes CH. Designed cefuroxime axetil formulations had good qualities and could be added as a new product to Iran drug marketing.

A sample of these curves is shown in Figure 2. For the assay solution 5 ml of suspension was dissolved in 50 ml methanol and after shaking for 5 minutes ml of medium was added and after achieving Since suspnesion is not absorbed orally, the 1-acetyloxyethyl axetil ester of cefuroxime was used to improve its gastrointestinal absorption.

In Figure 1 the percentage of release in all the formulations are presented.

Received Aug 28; Accepted Nov According to the obtained results and considering the ideal characteristics of prepared suspension formulations, formmulasi product can be added to drug market. Conclusion According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market. Cefuroxime is the second generation cephalosporin, which its intravenous and oral dosage forms are available. Bioequivalence evaluation of two brands of cefuroxime mg tablets cefuzime and zinnat in healthy volunteers.

Martin’s Physical Pharmacy and Pharmaceutical Sciences. According to the viscosity curves, the auspension were pseudo plastic, i.