Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.
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Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement | OMICS International
Six tablets from each formulation were tested for hardness. The drugs belongs to the biopharmaceutical classification system BCS class II and IV liquisold very poor dissolution leads to incomplete drug release from the formulation, increased dose, large inter and intra-subject plasma concentration variation under both fed and fasted states eventually leads to poor bioavailability [ 34 ].
Liquisolid lliquisolid are acceptably flowing and compressible powder forms of liquid medications. From the results of different batches prepared by three different carriers shown in Table 6it was found that Neusilin proved to be the superior carrier than others.
The maximum liquid load on the carrier material is termed as the liquid load factor Lf. Home Publications Conferences Register Contact. Spireas S Liquisolid systems and methods of preparing same.
The was then used to decide the optimum amount of carrier and coating materials required to ensure dry-looking, free-flowing and compactible powdered systems. On the other hand, if a solid water-insoluble drug is formulated, it should be initially dissolved or suspended in suitable nonvolatile solvent system to produce drug solution or drug suspension of desired concentration.
Thus, tablet weights are reduced in case of Fujicalin and Neusilin in comparison to commonly used carrier materials like Avicel.
Solubility of CBZ was determined in different non volatile solvents to finalise vehicle having maximum solubility. This indicates that there is no interaction between the drug and excipients. Therefore, it was essential to study the flowability of these liquisolid powder admixtures prior to compression. IntJ Pharm PharmSci 2: Usually, microcrystalline cellulose and colloidal silica are used as the carrier and the coating material, respectively.
Olmesartan appears to be more soluble in Acrysol EL than other vehicles. The liquisolid approach is a potential technology due to its simplified manufacturing method, cheaper production costs and the prospect of industrial scale up due to the good flow and compaction properties.
In the formulation development process solubility of active compound is one of the main criteria considered before deciding the dosage form. The less drug concentration in the vehicle means more fraction of the drug is liable to be in the liquid solution form i. Supernatant was filtered through membrane filter using 0. As a most discussed but still not completely resolved issue, solubility or dissolution enhancement techniques remain the most vibrant field for the researchers in formulation science.
The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. Characteristic peaks of the individual excipients were also retained; also no new peak was found in drug-loaded mixture of the excipients to be formulated in liquisolids.
DSC was used for the investigation of any interaction between the drug and its excipients. A powder may be able to retain only limited amounts of liquid while maintaining acceptable flow and compression properties. Solubility data of drug olmesartan medoxomil in various liquid vehicles is shown in Table 2. At higher values the greater amount of carrier may overcome to some extent the flow properties of powder.
Formulation containing Neusilin-Neusilin and Neusilin- Aerosil showed no disintegration while all other formulations showed disintegration up to seconds.
Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement
Formulation FA3 containing Fujicalin exhibited lower mean dissolution time and higher dissolution efficiency than all other formulations including marketed tablet. The highest liquid factor was obtained for Neusilin, and accordingly, the amount of carrier was lower than other formulations. It can be concluded from this study that novel porous carriers are superior to traditional carriers in liquisolid systems and are suitable for loading high dose drugs like CBZ.
The appropriate amounts cimpacts carrier and coating materials used for each formulation depend upon of that formulation. Guidelines Upcoming Special Issues. Due to significantly increased wetting properties and surface area of the drug particles available for dissolution, liquisolid tablets were expected to enhance drug release characteristics and, consequently, improved oral bioavailability.
The dissolution profiles of the liquisolid tablets for fast release formulations and conventional tablets of olmesartan tablets are shown in Figures 5 a and 5 b. It is a prodrug rapidly deesterified during absorption from the gastrointestinal tract to produce an active metabolite, olmesartan [ 7 ].
The weight of formulations containing Neusilin and Fujicalin ranged in between 0. Hence, the objective liquisoolid the present work was to formulate the liquisolid compacts for olmesartan medoxomil to improve the solubility and dissolution rate, which can increase clinical efficacy or reduce the oral dosage required to achieve the same effect.
Concentration loquisolid dissolved drug was determined using standard equation. Formulated liquisolid compacts showed all physical parameters within prescribed limit. Composition of liquids solid compacts batches is shown in Table 1.
compscts Solubility of olmesartan medoxomil was determined in various nonvolatile solvents. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil
From the dissolution profiles, it can be seen that all liquisolid formulations significantly improved drug dissolution compared to conventional tablets. Powder flowability is crucial in the industrial production of tablet dosage forms, as a uniform powder stream through hopper confirms uniformity of both tablet weight and luquisolid content.
To calculate the required amounts of powder excipients including both carrier and coating materials a mathematical approach for the formulation of A powder may be able to retain only limited amounts of liquid while maintaining acceptable flow and compression properties. This could be probably due to the presence of higher amounts of silica in and lower in.
This indicates acceptable resistance was shown by liquisolid tablets to withstand handling. The several mechanisms by which solubility enhancement takes place have been postulated for liquisolid systems.
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Cpmpacts thermogram showed a sharp endothermic peak at of A Novel Approach to Solubility Enhancement. Related article at PubmedScholar Google. Ann Jose ankara escort.